Ferdinando Nicoletti Selected Research

Saquinavir (Invirase)

10/2012	Therapeutic potential of nitric oxide-modified drugs in colon cancer cells.
8/2012	Unique antineoplastic profile of Saquinavir-NO, a novel NO-derivative of the protease inhibitor Saquinavir, on the in vitro and in vivo tumor formation of A375 human melanoma cells.
7/2011	Cytotoxic and immune-sensitizing properties of nitric oxide-modified Saquinavir in iNOS-positive human melanoma cells.
2/2011	In vitro and in vivo anticancer action of Saquinavir-NO, a novel nitric oxide-derivative of the protease inhibitor saquinavir, on hormone resistant prostate cancer cells.
12/2010	Anticancer effects of the nitric oxide-modified saquinavir derivative saquinavir-NO against multidrug-resistant cancer cells.
5/2009	The antitumor properties of a nontoxic, nitric oxide-modified version of saquinavir are independent of Akt.

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Ferdinando Nicoletti Research Topics

Disease

58	Neoplasms (Cancer) 01/2022 - 06/2004
27	Alzheimer Disease (Alzheimer's Disease) 02/2022 - 08/2002
25	Multiple Sclerosis 01/2022 - 07/2002
17	Pain (Aches) 01/2022 - 01/2007
17	Inflammation (Inflammations) 01/2021 - 10/2004
17	Schizophrenia (Dementia Praecox) 01/2021 - 08/2007
15	Autoimmune Diseases (Autoimmune Disease) 01/2021 - 07/2005
15	Parkinson Disease (Parkinson's Disease) 01/2020 - 12/2002
14	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2021 - 09/2002
12	Absence Epilepsy (Childhood Absence Epilepsy) 05/2022 - 07/2011
12	Neuralgia (Stump Neuralgia) 01/2022 - 06/2006
12	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2020 - 10/2004
11	Seizures (Absence Seizure) 05/2022 - 08/2005
11	Neuroinflammatory Diseases 07/2021 - 07/2002
10	Cognitive Dysfunction 05/2022 - 06/2005
9	Ischemia 01/2018 - 06/2007
8	COVID-19 01/2022 - 07/2020
8	Melanoma (Melanoma, Malignant) 10/2019 - 09/2008
8	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2018 - 05/2006
8	Breast Neoplasms (Breast Cancer) 11/2016 - 12/2010
7	Infections 01/2022 - 03/2007
7	Migraine Disorders (Migraine) 01/2021 - 03/2009
6	Chronic Pain 01/2022 - 01/2007
6	Brain Ischemia (Cerebral Ischemia) 06/2021 - 03/2005
6	Neuroblastoma 03/2020 - 10/2015
6	Psychotic Disorders (Schizoaffective Disorder) 11/2019 - 03/2011
6	Parkinsonian Disorders (Parkinsonism) 08/2015 - 12/2002
5	Dementia (Dementias) 02/2022 - 06/2005
5	Colitis 01/2022 - 12/2003
5	Rheumatoid Arthritis 12/2021 - 04/2010
5	Prostatic Neoplasms (Prostate Cancer) 01/2020 - 01/2005
5	Glioma (Gliomas) 01/2018 - 03/2003
5	Pleurisy (Pleuritis) 08/2014 - 10/2004
4	Epilepsy (Aura) 05/2022 - 12/2008
4	Infarction (Infarctions) 06/2021 - 06/2007
4	Hypoxia (Hypoxemia) 06/2021 - 07/2003
4	Major Depressive Disorder (Major Depressive Disorders) 01/2021 - 01/2017
4	Stroke (Strokes) 06/2020 - 11/2013
4	Arthritis (Polyarthritis) 11/2019 - 11/2005
4	Glioblastoma (Glioblastoma Multiforme) 09/2018 - 01/2018
4	Mental Disorders (Mental Disorder) 01/2017 - 12/2015
4	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 08/2015 - 12/2003

Drug/Important Bio-Agent (IBA)

45	Pharmaceutical PreparationsIBA 05/2022 - 08/2002
39	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA 05/2022 - 12/2002
29	Glutamic Acid (Glutamate)FDA Link 05/2022 - 07/2003
20	Proteins (Proteins, Gene)FDA Link 02/2022 - 08/2003
20	CytokinesIBA 05/2020 - 09/2002
16	Macrophage Migration-Inhibitory FactorsIBA 12/2021 - 07/2005
12	LigandsIBA 01/2019 - 10/2004
11	Brain-Derived Neurotrophic Factor (BDNF)IBA 02/2022 - 04/2009
11	saquinavir-NOIBA 01/2017 - 05/2009
10	KynurenineIBA 12/2020 - 06/2014
9	Analgesics (Analgesic Drugs)IBA 01/2022 - 01/2007
9	Nitric Oxide (Nitrogen Monoxide)FDA Link 04/2020 - 09/2008
8	InterleukinsIBA 12/2019 - 02/2002
8	Amyloid beta-PeptidesIBA 12/2012 - 08/2002
7	Antipsychotic Agents (Antipsychotics)IBA 12/2020 - 03/2012
7	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2020 - 04/2010
6	Antiviral Agents (Antivirals)IBA 01/2022 - 09/2011
6	Biomarkers (Surrogate Marker)IBA 01/2022 - 11/2014
6	HIV Protease InhibitorsIBA 10/2019 - 05/2009
6	3-phenyl-4,5-dihydro-5-isoxazole acetic acidIBA 03/2016 - 03/2007
6	Saquinavir (Invirase)FDA Link 10/2012 - 05/2009
6	SteroidsIBA 05/2011 - 01/2005
5	Sirolimus (Rapamycin)FDA Link 01/2022 - 09/2009
5	Fingolimod Hydrochloride (FTY720)FDA Link 01/2022 - 01/2013
5	EnzymesIBA 01/2022 - 05/2006
5	Reactive Oxygen Species (Oxygen Radicals)IBA 08/2021 - 03/2008
5	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2021 - 03/2012
5	Messenger RNA (mRNA)IBA 06/2020 - 10/2013
5	Monoclonal AntibodiesIBA 04/2020 - 10/2004
5	Antineoplastic Agents (Antineoplastics)IBA 01/2018 - 08/2009
5	Endothelin-1 (Endothelin 1)IBA 01/2017 - 06/2007
5	DNA (Deoxyribonucleic Acid)IBA 05/2013 - 10/2006
5	LY 341495IBA 10/2012 - 03/2003
5	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 09/2012 - 01/2004
4	AntioxidantsIBA 02/2022 - 08/2015
4	Acetylcarnitine (Alcar)IBA 01/2022 - 06/2006
4	Freund's AdjuvantIBA 01/2022 - 10/2012
4	cinnabarinic acidIBA 01/2022 - 06/2014
4	Hormones (Hormone)IBA 01/2021 - 02/2011
4	dopachrome isomeraseIBA 01/2021 - 10/2019
4	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 01/2021 - 08/2009
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2021 - 10/2004
4	Interleukin-6 (Interleukin 6)IBA 01/2021 - 02/2002
4	DDTIBA 01/2021 - 10/2019
4	LipopolysaccharidesIBA 11/2020 - 01/2002
4	N- cyclobutyl- 6- ((3- fluorophenyl)ethynyl)nicotinamideIBA 11/2020 - 11/2013
4	Biological ProductsIBA 07/2020 - 12/2012
4	xanthurenic acidIBA 01/2019 - 12/2015
4	Antidepressive Agents (Antidepressants)IBA 01/2018 - 10/2011
4	beta CateninIBA 02/2017 - 04/2008
4	AntigensIBA 01/2017 - 05/2008
4	MTOR InhibitorsIBA 11/2016 - 07/2011
4	17-triol 7 17-ethynyl-5-androstene-3IBA 01/2012 - 04/2010
4	CarrageenanIBA 10/2010 - 10/2004

Therapy/Procedure

36	Therapeutics 05/2022 - 06/2003
12	Analgesia 01/2022 - 06/2006
6	Drug Therapy (Chemotherapy) 01/2018 - 01/2007
4	Injections 01/2021 - 03/2005